Crosslinking Reagents
TARGETMOL CHEMICALS INC Mc-Val-Cit-PAB-Cl 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively. Purity 99.79%
Cayman Chemical nrIdronIc AcId 50mg
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
eMolecules 2-Pyridinylboronic acid MIDA ester | Combi-Blocks, Inc. | 1104637-58-2 | MFCD16621460 | 234.020 | C10H11BN2O4 | 95.000 | CN1CC(=O)OB(OC(=O)C1)c1ccccn1 | 250mg | 603232701
2-Pyridinylboronic acid MIDA ester | Combi-Blocks, Inc. | 1104637-58-2 | MFCD16621460 | 234.020 | C10H11BN2O4 | 95.000 | CN1CC(=O)OB(OC(=O)C1)c1ccccn1 | 250mg | 603232701
Cayman Chemical FlutIcason PropIonate 10mg
A synthetic corticosteroid and glucocorticoid receptor agonist; inhibits AP-1-mediated transcription in a transrepression assay using ChaGo-K-1 cells (IC50 = 0.04 nM); selectively binds to the glucocorticoid receptor (IC50 = 0.0009 µM) over the progesterone, mineralocorticoid, and androgen receptors (IC50s = 0.021, 0.149, and >10 µM, respectively), as well as ERα and ERβ (IC50s = >10 µM for both); increases apoptosis of T cells isolated from human peripheral blood and induces spontaneous apoptosis of primary human eosinophils (EC50 = 3.7 nM); completely inhibits congestion in a guinea pig model of ovalbumin-induced allergic rhinitis when administered as a 0.5 mg/ml solution at 20 µl/nostril; reduces ovalbumin-induced increases in IL-4 in nasal lavage fluid in the same model; potentiates Kv1 currents in an inside-out patch-clamp assay (EC50 = 37 nM)
Medchemexpress LLC Lys-Nε-MCC-DM1 | 1281816-04-3 | 99.6% | 1103.71 g·mol⁻¹ | C53H75ClN6O15S | 5 MG
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a linker-payload conjugate and active metabolite used in antibody-drug conjugate (ADC) research. It inhibits tubulin polymerization and is used for linker development, payload characterization, and in vitro pharmacology studies.
- High purity (>99.6%) suitable for analytical work.
- Molecular weight 1103.71 g·mol⁻¹.
- Chemical formula C53H75ClN6O15S.
- Inhibits tubulin polymerization for mechanism studies.
- Intended for ADC linker-payload and metabolite research.
- Provided as a solid convenient for storage and handling.
Chem-Impex International, Inc. Propargyl-NHS ester | MFCD13184973 | 250MG
Propargyl-NHS ester , Purity: 99% , Mol Wt: 225.20 , 1174157-65-3 , MFCD13184973 , 250 mg
Cell Signaling Technology Posibeadstm G4S Linker Positive Control Beads 250 ul
Posibeadstm G4S Linker Positive Control Beads 250 ul
eMolecules Ambeed DSG Crosslinker 250mg 534086561 A880434 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
Ambeed DSG Crosslinker 250mg 534086561 A880434 0 000 79642-50-5 MFCD00153597 326 261 C13H14N2O8
American Research Products Inc SMCC ACTIVATED PEROXIDASE HRP
5000265054 SMCC ACTIVATED PEROXIDASE HRP
Cayman Chemical Sulfo-SMCCsodIum salt 250mg
A water-soluble protein cross-linking reagent; has been used to conjugate anti-PD-L1 antibodies to the surface of platelets and Golgi-targeting peptides to platelet microparticle-mimetic nanoplatforms