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Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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DSG-PEG (MW 2000) is a PEGylated lipid used as a steric-stabilizing component in liposome and lipid nanoparticle formulations for research. It provides a methoxy-terminated polyethylene glycol chain (average MW 2000) conjugated to a distearoyl glycerol backbone, supplied as a high-purity reagent for formulation studies.
Pegylated lipid with average molecular weight 2000.
Provides steric stabilization to liposomes and lipid nanoparticles.
Suitable for liposome preparation and PEGylated formulations.
High purity suitable for research applications.
Available in milligram and gram pack sizes for formulation work.
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Methyltetrazine-DBCO is a heterobifunctional click chemistry reagent used as a non-cleavable antibody-drug conjugate (ADC) linker. It contains a DBCO moiety for strain-promoted alkyne-azide cycloaddition (SPAAC) with azides, and a methyltetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners.
Non-cleavable ADC linker suitable for bioconjugation.
Enables SPAAC reactions via the DBCO group.
Supports iEDDA reactions via the methyltetrazine moiety.
Molecular weight 683.73 and formula C34H33N7O7S.
Appearance: solid, purple to purplish red.
Purity approximately 95.2% (as supplied).
Available in small-scale packages, including 5 mg.
Storage: powder at -20°C (long term) or 4°C (shorter term); in solvent at -80°C or -20°C for limited durations.
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An amine-reactive reagent; has been used as a derivatization reagent to identify PTMs in lysine-rich proteins and novel cell surface proteins of R. rickettsii
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A peptide linker molecule; cleaved by cathepsin B; has been used in the synthesis of ADCs containing KGP05 or MMAD, as well as α-galactosylceramide or folic acid conjugates that target peptide antigens to natural killer T cells or CRM1 inhibitors to cancer cells, respectively
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A NSAID and COX-2 inhibitor; binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid in vitro (Ki = 10 µM); reduces acetic acid-induced writhing in rats at 30 mg/kg; inhibits DNBC-induced increases in skin thickness in a mouse model of delayed-type hypersensitivity; reduces the antibody response to sheep red blood cells in mice
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